Enteric Coatings IV*

In Vivo Testing of Granules and Tablets Coated With Styrene-Maleic Acid Copolymer
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      Preliminary tests in human subjects have indicated that the period of time which tablets coated with styrene-maleic acid copolymer, dibutyl phthalate, and talc resist the stomach contents of human subjects appears to be well predicted by an in vitro test in simulated gastric fluid U. S. P. Both freshly coated granules and stability samples of tablets coated with this formulation disintegrated rapidly in the small intestine of the dogs and human subjects, respectively. The site of disintegration was the duodenum or jejunum where optimal absorption of many therapeutic agents would be expected.
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        • Lozinski E.
        • Diver G.R.
        This Journal. 1933; 22: 143
        • Bukey F.S.
        • Brew M.
        ibid. 1934; 23: 1217
        • Editorial
        New Engl. J. Med. 1956; 254: 963
      1. Convreur, A., and Collaborators, Partial Translation of “Les Enrobages Modernes Des Drageés et Des Pilules,” translated and distributed by Distillation Products Industries, Division of Eastman Kodak Co., Rochester 3, N. Y.

        • Crane A.W.
        • Wruble M.
        Am. J. Roentgenol. Radium Therapy. 1938; 39: 450
        • Tarnowski C.E.
        Am. Rev. Tuberc. Pulmonary Diseases. 1957; 76: 159
        • Hinkle C.L.
        Am. J. Roentgenol. Radium Therapy. 1951; 65: 575
        • Hodge H.C.
        • Forsyth H.H.
        • Ramsey G.H.
        J. Pharmacol. Exptl. Therap. 1944; 80: 241
        • Clymer H.A.
        • Donnell M.
        (to Smith Kline & French Laboratories) U. S. pat. 2,540,970. 1951 (February 6)
        • Abbott Laboratories
        British pat. specification 760.403. 1956 (October 31)
        • Wagner J.G.
        • Long S.
        This Journal. 1960; 48: 121
        • Wagner J.G.
        • Veldkamp W.
        • Long S.
        ibid. 1958; 47: 681
        • Hunt J.N.
        Physiol. Revs. 1959; 39: 491
        • Wagner J.G.
        (to the Upjohn Co.), U. S. pat. 2,897,121. 1959 (July 28)
      2. Wagner, J. G., Carpenter, O. S., and Collins, E. J., J. Pharmacol. Exptl. Therap., in press.